Cocaine: Cocaine hydrochloride and crack cocaine are widely available in most West Virginia cities. Crack cocaine abuse generally remains confined to low and low-middle income individuals, but crosses all ethnic lines. There is some violence associated with the crack trade in the state. Cocaine availability is limited to large-retail or small-wholesale quantities. Source areas for cocaine are more varied than for other drugs consumed in the state and are largely based on the trafficker's location within West Virginia.

Heroin: Both the demand for and the availability of heroin are very limited throughout West Virginia. Small enclaves of long-term heroin addicts exist, who rely on one another to procure supplies of heroin from secondary source cities such as Philadelphia and Baltimore. The heroin sold in West Virginia typically retains the street/brand name and packaging of the Philadelphia or Baltimore-area supplier.

Methamphetamine:Clandestine methamphetamine laboratory activity in West Virginia has increased threefold in the past several years. Previously, methamphetamine manufacture appeared to be centered in the Panhandle region of the state, but has expanded to include other areas of northern West Virginia as well as some clandestine laboratory sites in the southeastern portion of the state bordering Kentucky and Virginia. In addition, methamphetamine distributors in West Virginia often share Mexican sources of supply with distributors in Virginia's Shenandoah Valley region.

Club Drugs: There is increased demand for MDMA throughout West Virginia, but abuse remains fairly concentrated near Morgantown, the location of West Virginia University. Demand for MDMA in college towns is sufficient to ensure that thousands of the pills reach West Virginia every month. Because of West Virginia's remote terrain, the area is purported to host numerous private "rave" parties but attendance at large-scale, publicized raves has been disappointing to promoters.

Marijuana: Both imported and domestic, locally-cultivated marijuana pose a serious drug threat in West Virginia. Although the state ranks 37th in population in the U.S., West Virginia consistently ranks in the top ten states for marijuana eradication. West Virginia commonly serves as a source area for domestic marijuana. The Appalachia HIDTA was established initially to combat marijuana cultivation in the tri-state area - Ohio, Kentucky and West Virginia - although that mission has expanded.