Cocaine: Cocaine HCl is readily available throughout all parts of South Dakota.While the availability of crack cocaine is increasing in eastern South Dakota, abuse is still limited in western sections of the state. The cocaine is obtained from Mexican sources in Sioux City, Iowa; Kansas City, Missouri; and California. In addition some distributors in Rapid City, South Dakota obtain cocaine from sources in the Denver area.

Heroin: Heroin is typically available only in personal use quantities in South Dakota.

Methamphetamine: The availability of Mexican methamphetamine continues to increase throughout South Dakota. Methamphetamine in eastern South Dakota is obtained from sources in Sioux City, Iowa, or from sources in western states such as Texas, Arizona, and California. Methamphetamine is distributed locally by either long-time Caucasian residents or Hispanic males who have recently moved to South Dakota. Mexican methamphetamine in western South Dakota is primarily shipped directly from cities such as Denver, Phoenix, San Francisco, and San Diego using FedEx or UPS. Small toxic labs have steadily increased over the last few years. Local lab operators are obtaining chemicals at local hardware stores, truck stops, and department stores. Production capabilities of these small labs are usually less than one ounce. The stealing of anhydrous ammonia fertilizer from farm supply stores and farmers has also emerged as a serious problem in this agricultural state.

Predatory Drugs: MDMA (Ecstasy) in eastern South Dakota is limited but appears to be increasing. MDMA is more readily available in western portions of South Dakota; however, the number of rave parties remains stable. Law enforcement in South Dakota reports limited availability of LSD.

Marijuana: Marijuana is readily available throughout South Dakota. Multi-hundred pound quantities are transported into the state from the southwest border of the United States. Smaller quantities are also shipped via express mail services or purchased from Hispanic males in the Sioux City area and driven back to Sioux Falls. Higher purity marijuana is produced in indoor grow operations in the Sioux Falls area, which typically contain less than 100 plants. Larger indoor operations have been found in the Rapid City area in western South Dakota, ranging from a few plants to several hundred. During the past two years, members of the Oglala Sioux Tribe have attempted to plant fields of "hemp" on the Pine Ridge Indian Reservation in South Dakota.

Other Drugs: OxyContin is a growing problem throughout South Dakota, and has been found at methamphetamine laboratory sites. According to the South Dakota Department of Health, hydrocodone products, codeine, and Darvocet-N are the most popular abused pharmaceutical substances in the state. They are obtained by forged prescriptions and by phony call-ins.